Methylsulfonylmethane is a potential anticancer agent for the treatment of lung cancer. - GreenMedInfo Summary

n/a
Abstract Title:

Effect of Methylsulfonylmethane on Proliferation and Apoptosis of A549 Lung Cancer Cells Through G/M Cell-cycle Arrest and Intrinsic Cell Death Pathway.

Abstract Source:

Anticancer Res. 2020 Apr ;40(4):1905-1913. PMID: 32234879

Abstract Author(s):

Doh Hoon Kim, Nipin Sp, Dong Young Kang, Eun Seong Jo, Alexis Rugamba, Kyoung-Jin Jang, Young Mok Yang

Article Affiliation:

Doh Hoon Kim

Abstract:

BACKGROUND/AIM: Methylsulfonylmethane (MSM) is a natural organic compound that displays anti-inflammatory as well as antioxidant properties. MSM reportedly has potential in inhibition of tumor cells. However, molecular mechanisms underlying the effects of MSM on lung cancer remain unclear.

MATERIALS AND METHODS: In this study, the effect of MSM on A549 cells was examined. We focused on the mode of apoptosis induced by MSM and investigated alterations in the integrity of the outer membrane of mitochondria.

RESULTS: Our results showed that MSM inhibited viability of A549 cells and changed the shape and permeability of nuclei. In addition, MSM induced G/M arrest. MSM reduced the mitochondrial membrane potential and contributed to release of cytochrome c from mitochondria to cytoplasm.

CONCLUSION: MSM is a potential anticancer agent for the treatment of lung cancer.

Article Published Date : Mar 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : MSM (Methylsulfonylmethane) : CK(137) : AC(33)
Diseases : Lung Cancer : CK(2308) : AC(999)
Pharmacological Actions : Antiproliferative : CK(6801) : AC(5032), Apoptotic : CK(6986) : AC(5304)

Print Options

Some features are currently member only features. If you are already a member, please login. Otherwise, click here to become a member.

Key Research Topics

Substance

MSM (Methylsulfonylmethane)

Disease

Lung Cancer

Pharmacological Actions

Apoptotic
Antiproliferative
Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

Connect with GreenMedInfo

MeWe

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.