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Article Publish Status: FREE
Abstract Title:

Methylsulfonylmethane sensitizes endometrial cancer cells to doxorubicin.

Abstract Source:

Cell Biol Toxicol. 2020 Jun 20. Epub 2020 Jun 20. PMID: 32562081

Abstract Author(s):

Karolina Kowalska, Dominika Ewa Habrowska-Górczyńska, Dominika Kurczewska, Kamila Domińska, Kinga Anna Urbanek, Agnieszka Wanda Piastowska-Ciesielska

Article Affiliation:

Karolina Kowalska

Abstract:

BACKGROUND: Methylsulfonylmethane (MSM) is a commonly used diet supplement believed to decrease the inflammation in joints and fastens recovery in osteoarthritis, gastric mucosal injury, or obesity-related disorders. It was also suggested that MSM might play a beneficial role in cancer treatment.

PURPOSE: So far, the MSM might have a potentially beneficial effect in endometrial cancer (EC) treatment.

STUDY DESIGN: This study evaluated the effect and usefulness of MSM in combinatory therapy with known drug doxorubicin (DOX).

METHODS: The effect of combinational treatment of MSM and DOX on the induction of apoptosis was evaluated in EC cell lines (ISHIKAWA, MFE-296, MFE-280).

RESULTS: We observed that MSM itself induces apoptosis in EC cell lines, and pre-treatment with MSM for 24 h increases the sensitivity of EC cells to DOX-induced apoptosis and DNA damage and that effect might be regulated by p42/44 (Erk1/2) MAPK and Akt (protein kinase B).

CONCLUSION: These results for the first time show that MSM might act as a sensitizer of EC cells to known drugs, for which EC cells quickly acquire resistance. Graphical abstract.

Study Type : In Vitro Study

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