n/a

Article Publish Status: FREE
Abstract Title:

Methylsulfonylmethane sensitizes endometrial cancer cells to doxorubicin.

Abstract Source:

Cell Biol Toxicol. 2020 Jun 20. Epub 2020 Jun 20. PMID: 32562081

Abstract Author(s):

Karolina Kowalska, Dominika Ewa Habrowska-Górczyńska, Dominika Kurczewska, Kamila Domińska, Kinga Anna Urbanek, Agnieszka Wanda Piastowska-Ciesielska

Article Affiliation:

Karolina Kowalska

Abstract:

BACKGROUND: Methylsulfonylmethane (MSM) is a commonly used diet supplement believed to decrease the inflammation in joints and fastens recovery in osteoarthritis, gastric mucosal injury, or obesity-related disorders. It was also suggested that MSM might play a beneficial role in cancer treatment.

PURPOSE: So far, the MSM might have a potentially beneficial effect in endometrial cancer (EC) treatment.

STUDY DESIGN: This study evaluated the effect and usefulness of MSM in combinatory therapy with known drug doxorubicin (DOX).

METHODS: The effect of combinational treatment of MSM and DOX on the induction of apoptosis was evaluated in EC cell lines (ISHIKAWA, MFE-296, MFE-280).

RESULTS: We observed that MSM itself induces apoptosis in EC cell lines, and pre-treatment with MSM for 24 h increases the sensitivity of EC cells to DOX-induced apoptosis and DNA damage and that effect might be regulated by p42/44 (Erk1/2) MAPK and Akt (protein kinase B).

CONCLUSION: These results for the first time show that MSM might act as a sensitizer of EC cells to known drugs, for which EC cells quickly acquire resistance. Graphical abstract.

Study Type : In Vitro Study

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.