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Article Publish Status: FREE
Abstract Title:

Mindfulness-Based Stress Reduction-related changes in posterior cingulate resting brain connectivity.

Abstract Source:

Soc Cogn Affect Neurosci. 2019 Jul 31 ;14(7):777-787. PMID: 31269203

Abstract Author(s):

Tammi R A Kral, Ted Imhoff-Smith, Douglas C Dean, Dan Grupe, Nagesh Adluru, Elena Patsenko, Jeanette A Mumford, Robin Goldman, Melissa A Rosenkranz, Richard J Davidson

Article Affiliation:

Tammi R A Kral

Abstract:

Mindfulness meditation training has been shown to increase resting-state functional connectivity between nodes of the frontoparietal executive control network (dorsolateral prefrontal cortex [DLPFC]) and the default mode network (posterior cingulate cortex [PCC]). We investigated whether these effects generalized to a Mindfulness-Based Stress Reduction (MBSR) course and tested for structural and behaviorally relevant consequences of change in connectivity. Healthy, meditation-naïve adults were randomized to either MBSR (N = 48), an active (N = 47) or waitlist (N = 45) control group. Participants completed behavioral testing, resting-state fMRI scans and diffusion tensor scans at pre-randomization (T1), post-intervention (T2) and ~5.5 months later (T3). We foundincreased T2-T1 PCC-DLPFC resting connectivity for MBSR relative to control groups. Although these effects did not persist through long-term follow-up (T3-T1), MBSR participants showed a significantly stronger relationship between days of practice (T1 to T3) and increased PCC-DLPFC resting connectivity than participants in the active control group. Increased PCC-DLPFC resting connectivity in MBSR participants was associated with increased microstructural connectivity of a white matter tract connecting these regions and increased self-reported attention. These data show that MBSR increases PCC-DLPFC resting connectivity, which is related to increased practice time, attention and structural connectivity.

Study Type : Human Study
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