Vitamins E and C ameliorate the oxidative stresses induced by zinc oxide nanoparticles on liver and gills of.
Saudi J Biol Sci. 2019 Feb ;26(2):357-362. Epub 2018 Jul 2. PMID: 31485177
The current study evaluated the hazards of Zinc oxide nanoparticles (ZnONPs) onliver and gill antioxidants enzymes activities and antioxidants genes expressions. The ameliorative action of vitamins E and C mixture was investigated. Two hundred males ofwere exposed to one and two mg Lof ZnONPs either with or without vitamin C and E mixture for 7 and 15 days. Glutathione reductase (GR), glutathione peroxidase (GPx) and glutathione-S-transferase (GST) activities and gene expression as well glutathione (GSH) and lipid peroxide (LPO) levels were investigated. The results revealed that the exposure to ZnONPs could induce alterations in the liver andgills antioxidants and LPO of. Moreover, the mixture of vitamin E and C highly effective in alleviation the toxic effect of ZnONPs.