Abstract Title:

Modulation of antioxidant defense system in response to berberine in Candida albicans.

Abstract Source:

Yeast. 2020 Nov 3. Epub 2020 Nov 3. PMID: 33141949

Abstract Author(s):

Evida Poopedi, Musa Marimani, Suliman Yousef AlOmar, Badr Aldahmash, Aijaz Ahmad

Article Affiliation:

Evida Poopedi


Emergence of multidrug resistant species of Candida is evolving, which advocates an urgent need for the development of new therapeutic strategies and antifungal drugs. Activation of antioxidant defense system in Candida albicans is known as forefront mechanism to escape drug toxicity. This study evaluated the role of antioxidant defense genes in the susceptibility to fluconazole in C. albicans. And also determined the effect of berberine on growth, antioxidant enzymes and the expression of their genes in C. albicans isolates. Expression of major antioxidant genes was significantly increased in fluconazole resistant isolates in comparison to the susceptible group. Antifungal susceptibility against berberine showed MIC values ranging from 125 to 500μg/ml. Berberine treatment caused upregulation of mRNA expression and enzymatic activities of the targeted major antioxidants. Interestingly, C. albicans exhibited efficient antioxidant response at lower concentrations but could not sufficiently alleviate berberine-induced oxidative stress occurring at concentrations above 250 μg/ml. Therefore, berberine could serve as a potent ROS-inducing agent, disrupting the antioxidant system especially in fluconazole resistant C. albicans to overcome antifungal drug resistance.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Antifungal Agents : CK(403) : AC(237)

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.