Abstract Title:

Modulation by hydroxytyrosol of oxidative stress and antitumor activities of paclitaxel in breast cancer.

Abstract Source:

Eur J Nutr. 2018 Feb 21. Epub 2018 Feb 21. PMID: 29468462

Abstract Author(s):

Nuri El-Azem, Mario Pulido-Moran, Cesar L Ramirez-Tortosa, Jose L Quiles, Francisca E Cara, Pedro Sanchez-Rovira, Sergio Granados-Principal, MCarmen Ramirez-Tortosa

Article Affiliation:

Nuri El-Azem


PURPOSE: The main objective of this study was to test the therapeutic potential of hydroxytyrosol and its combination with paclitaxel in breast cancer on oxidative stress status.

METHODS: Impact on proliferation rates of different chemotherapy administration patterns was assayed in MCF-7 and MDA-MB-231 breast cancer cell lines. Breast tumor-bearing rats were randomly assigned to Control, Hydroxytyrosol, Paclitaxel and Paclitaxel plus hydroxytyrosol groups, for 6 weeks. Tumor volume, cell proliferation and several systemic oxidative stress parameters were measured. Anti-proliferative activity in vitro experiments was correlated with in vivo experiments.

RESULTS: Combination group did significantly reduce tumor volume when compared with paclitaxel alone. Additionally, the combination improved the antioxidant status without compromising the antitumor activity of standard chemotherapy.

CONCLUSION: These findings reveal for the first time that hydroxytyrosol is an active partner in combined therapies with paclitaxel against breast cancer. Combination with hydroxytyrosol would also ensure a less oxidative impact of chemotherapeutic drugs that could potentially improve patient wellness.

Study Type : In Vitro Study

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