n/a
Article Publish Status: FREE
Abstract Title:

Molecular iodine exerts antineoplastic effects by diminishing proliferation and invasive potential and activating the immune response in mammary cancer xenografts.

Abstract Source:

BMC Cancer. 2019 Mar 22 ;19(1):261. Epub 2019 Mar 22. PMID: 30902074

Abstract Author(s):

Irasema Mendieta, Rosa E Nuñez-Anita, Mario Nava-Villalba, Xóchitl Zambrano-Estrada, Evangelina Delgado-González, Brenda Anguiano, Carmen Aceves

Article Affiliation:

Irasema Mendieta

Abstract:

BACKGROUND: The immune system is a crucial component in cancer progression or regression. Molecular iodine (I) exerts significant antineoplastic effects, acting as a differentiation inductor and immune modulator, but its effects in antitumor immune response are not elucidated.

METHODS: The present work analyzed the effect of Iin human breast cancer cell lines with low (MCF-7) and high (MDA-MB231) metastatic potential under both in vitro (cell proliferation and invasion assay) and in vivo (xenografts of athymic nude mice) conditions.

RESULTS: In vitro analysis showed that the 200 μM Isupplement decreases the proliferation rate in both cell lines and diminishes the epithelial-mesenchymal transition (EMT) profile and the invasive capacity in MDA-MB231. In immunosuppressed mice, the Isupplement impairs implantation (incidence), tumoral growth, and proliferation of both types of cells. Xenografts of the animals treated with Idecrease the expression of invasion markers like CD44, vimentin, urokinase plasminogen activator and its receptor, and vascular endothelial growth factor; and increase peroxisome proliferator-activated receptor gamma. Moreover, in mice with xenografts, the Isupplement increases the circulating level of leukocytes and the number of intratumoral infiltrating lymphocytes, some of them activated as CD8+, suggesting the activation of antitumor immune responses.

CONCLUSIONS: Idecreases the invasive potential of a triple negative basal cancer cell line, and under in vivo conditions the oral supplement of this halogen activates the antitumor immune response, preventing progression of xenografts from laminal and basal mammary cancer cells. These effects allow us to propose iodine supplementation as a possible adjuvant in breast cancer therapy.

Print Options


Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.