Article Publish Status: FREE
Abstract Title:

Molecular mechanisms of the action of Arctigenin in cancer.

Abstract Source:

Biomed Pharmacother. 2018 Dec ;108:403-407. Epub 2018 Sep 17. PMID: 30236849

Abstract Author(s):

Yinghua He, Qiaomei Fan, Tiantian Cai, Wei Huang, Xianze Xie, Yayun Wen, Zheng Shi

Article Affiliation:

Yinghua He


Since antediluvian times, the scientific community has realized that natural compounds exhibit enormous potential for the treatment of terrible diseases, such as cancer. Despite a variety of effective bioactive molecules, effective therapies still need to be developed to treat cancer. Hence, it is necessary to study the interactions of natural molecules with their cellular targets. Arctigenin (ATG), a natural lignan compound extracted from Arctium lappa, inhibits the growth of various cancer cells, such as those of the stomach, lungs, liver, and colon, as well as leukocytes, and regulates numerous intracellular activities, such as antioxidative, anti-inflammatory, and anticancer activities. The intention of this paper is to summarize and generally analyse the molecular pathways that are involved in the anticancer effects of ATG. In addition, the interactions of ATG with other drugs are also highlighted in this paper.

Study Type : Review

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