Momordicinin showed potent α-amylase inhibitory activity. - GreenMedInfo Summary
Isolation, characterisation and investigation ofantidiabetic and antioxidant activity of phytoconstituents from fruit ofLinn.
Nat Prod Res. 2019 Jul 2:1-3. Epub 2019 Jul 2. PMID: 31264459
The dry powder of MC fruits was extracted by maceration, ultrasonication, liquid-liquid partition and soxhlation. Theantidiabetic and antioxidant assays were used to screen extracts and fractions. Refluxed and liquid partitioned extracts were fractionated using petroleum ether and ethyl acetate and purified with the help of preparative HPLC to give 2 phytoconstituents M1 and M2 respectively. Compound M1 (1) was identified as charantin and Compound M2 (2) was identified as momordicinin using spectral studies. Momordicinin showed potentα-amylase inhibitory activity with IC15.86μg/ml which was reported for the first time.