Monoterpene glycosides with anti-inflammatory activity from Paeoniae Radix. - GreenMedInfo Summary
Monoterpene glycosides with anti-inflammatory activity from Paeoniae Radix.
Fitoterapia. 2019 Aug 6 ;138:104290. Epub 2019 Aug 6. PMID: 31398448
Six new monoterpene glycosides, named 6'-O-nicotinoylalbiflorin (1), 4'-O-vanillylalbiflorin (2), paeonidanin L (3), paeoniflorigenin-1-O-β-d-xyloside (4), 6'-(2-hydroxypropanoyl)-paeoniflorin (5), oxylactiflorin (6), together with 16known ones (7-22) were isolated from the 70% ethanol extract of Paeoniae Radix. Their structures were elucidated based on spectroscopic analysis (1D and 2D NMR, HRESIMS, IR and UV), chemical evidences and comparison with literatures. The inhibitory effects of all the isolates were evaluated against lipopolysaccharide (LPS) stimulated PGEproduction in RAW 264.7 macrophages.