Article Publish Status: FREE
Abstract Title:

Seeds Improve Aging-Related Endothelial Dysfunction in Wistar Rats.

Abstract Source:

Oxid Med Cell Longev. 2019 ;2019:2567198. Epub 2019 May 13. PMID: 31214278

Abstract Author(s):

Joseph Iharinjaka Randriamboavonjy, Sandrine Heurtebise, Pierre Pacaud, Gervaise Loirand, Angela Tesse

Article Affiliation:

Joseph Iharinjaka Randriamboavonjy


Vascular aging is characterized by functional and structural changes of the vessel wall, including endothelial dysfunction, with decreased endothelial NObioavailability and elevated vasoconstrictor and inflammatory mediator production, vascular rigidity, and tone impairment.(MOI) is a little tree, and different parts of which are used in traditional medicine in tropical Africa, America, and Asia for therapeutic applications in several disorders including cardiovascular disease. The present study is aimed at assessing the effect of MOI on aging-associated alteration of the endothelial function in Wistar rats. Middle-aged Wistar rats (46-week-old males) have been fed with food containing or not 750 mg/kg/day of MOI seed powder for 4 weeks. A group of young Wistar rats (16-week-old) was used as control. Measurement of isometric contraction, western blot analysis, and immunostaining has then been performed in the aortas and mesenteric arteries to assess the endothelium function. MOI treatmentimproved carbachol-induced relaxation in both aortas and mesenteric arteries of middle-aged rats. In the aortas, this was associated with an increased Akt signalling and endothelial NO synthase activation and a downregulation of arginase-1. In the mesenteric arteries, the improvement of the endothelial-dependent relaxation was related to an EDHF-dependent mechanism. These results suggest a vascular protective effect of MOI seeds against the vascular dysfunction that develops during aging through different mechanisms in conductance and resistance arteries.

Study Type : Animal Study

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