Molecular effects of Moringa leaf extract on insulin resistance and reproductive function in hyperinsulinemic male rats.
J Diabetes Metab Disord. 2019 Dec ;18(2):487-494. Epub 2019 Nov 15. PMID: 31890674
Mona A Mohamed
Background: Many studies have reported that insulin resistance impairs the antioxidant defense system and causes male infertility.is a medicinal plant that has been employed for the medicament of many disorders. It controls the levels of glucose and manages male sexual disorders. However, its extracts can reverse insulin resistance-linked metabolic alterations remains unknown. Therefore, the current study investigated the potential of the aqueous leaves extract fromto reverse insulin resistance and testicular disorders in rats.
Methods: Rats were fed either a chow (as a control group) or a high fructose diet (HFD, to persuade a state of insulin resistance), in addition to a group of rats fed HFD and treated with(300 mg/kg) for 4 weeks.
Results: reversed hepatic insulin insensitivity and this was linked to up-regulation of genes involved in insulin receptors and glucose uptake in the liver. These results were associated with amended the insulin level in serum and standardization of insulin sensitivity. In addition, it improved the serum testosterone level and the gene expression of the testicular steridogenic acute regulatory protein (StAR) and 3β-hydroxysteroid dehydrogenase (3β-HSD).
Conclusion: Taken together, our findings demonstrate thatreversed HFD diet-induced insulin resistance and improved the testicular function.