Abstract Title:

Characterization of soluble dietary fiber from Moringa oleifera seeds and its immunomodulatory effects.

Abstract Source:

Int J Biol Macromol. 2016 Jun 6. Epub 2016 Jun 6. PMID: 27283233

Abstract Author(s):

Sandanamudi Anudeep, Vaddi K Prasanna, Shruthi M Adya, Cheruppanpullil Radha

Article Affiliation:

Sandanamudi Anudeep


Moringa oleifera (moringa or drumstick) seeds are a potential source of dietary fiber with 6.5% w/w soluble dietary fiber. Biochemical characterization of moringa seed soluble fiber revealed that it is a glycoprotein with 5% neutral sugars. Arabinose and xylose are the major neutral sugars identified by gas liquid chromatography (GLC). Moringa seed soluble fiber was identified as protease resistant - glycoprotein and termed as moringa seed resistant protein (MSRP). MSRP was found to be a homodimer (18kDa) containing two 9kDa monomeric units as revealed by SDS-PAGE analysis with pI 10.8. Immunostimulating activity of MSRP was assessed by murine splenocyte proliferation and production of NO from macrophages. MSRP at low concentration (0.01μg/well) strongly increased proliferation of splenocytes, while MSRP at high concentration weakly responded. MSRP induced 6-fold increase in NO production when compared to the control which indicates the activation of macrophages. MSRP isolated from defatted moringa seed flour is a potent mitogen,enhancing the proliferation of lymphocytes and inducing NO from macrophages. This study concludes that moringa seed is a potential nutritional source to promote the immune system of the host.

Study Type : In Vitro Study

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