Article Publish Status: FREE
Abstract Title:

Multivariate techniques enable a biochemical classification of children with autism spectrum disorder versus typically-developing peers: A comparison and validation study.

Abstract Source:

Bioeng Transl Med. 2018 May ;3(2):156-165. Epub 2018 Jun 19. PMID: 30065970

Abstract Author(s):

Daniel P Howsmon, Troy Vargason, Robert A Rubin, Leanna Delhey, Marie Tippett, Shannon Rose, Sirish C Bennuri, John C Slattery, Stepan Melnyk, S Jill James, Richard E Frye, Juergen Hahn

Article Affiliation:

Daniel P Howsmon


Autism spectrum disorder (ASD) is a developmental disorder which is currently only diagnosed through behavioral testing. Impaired folate-dependent one carbon metabolism (FOCM) and transsulfuration (TS) pathways have been implicated in ASD, and recently a study involving multivariate analysis based upon Fisher Discriminant Analysis returned very promising results for predicting an ASD diagnosis. This article takes another step toward the goal of developing a biochemical diagnostic for ASD by comparing five classification algorithms on existing data of FOCM/TS metabolites, and also validating the classification results with new data from an ASD cohort. The comparison results indicate a high sensitivity and specificity for the original data set and up to a 88% correct classification of the ASD cohort at an expected 5% misclassification rate for typically-developing controls. These results form the foundation for the development of a biochemical test for ASD which promises to aid diagnosis of ASD and provide biochemical understanding of the disease, applicable to at least a subset of the ASD population.

Study Type : Human Study

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