Article Publish Status: FREE
Abstract Title:

Mushroomβ-Glucan May Immunomodulate the Tumor-Associated Macrophages in the Lewis Lung Carcinoma.

Abstract Source:

Biomed Res Int. 2015 ;2015:604385. Epub 2015 Jun 17. PMID: 26167490

Abstract Author(s):

Wan-Jhen Wang, Yu-Sheng Wu, Sherwin Chen, Chi-Feng Liu, Shiu-Nan Chen

Article Affiliation:

Wan-Jhen Wang

Abstract:

The present study showed that oral mushroom beta-glucan treatment significantly increased IFN-γ mRNA expression but significantly reduced COX-2 mRNA expression within the lung. For LLC tumor model, oral Ganoderma lucidum or Antrodia camphorata polysaccharides treatments significantly reduced TGF-β production in serum. In addition, IL-12 and IFN-γ mRNA expression were significantly increased, but IL-6, IL-10, COX-2, and TGF-β mRNA expression were substantially following oral mushroom polysaccharides treatments. The study highlights the efficacious effect of mushroom polysaccharides for ameliorating the immune suppression in the tumor microenvironment. Increased M1 phenotype of tumor-associated macrophages and attenuated M2 phenotype of tumor-associated macrophages could be achieved by ingesting mushroom polysaccharides.

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