Endogenous-3 Polyunsaturated Fatty Acids Are Beneficial to Dampen CD8T Cell-Mediated Inflammatory Response upon the Viral Infection in Mice.
Int J Mol Sci. 2019 Sep 12 ;20(18). Epub 2019 Sep 12. PMID: 31547227
Kyung Won Kang
Omega-3 (-3) polyunsaturated fatty acids (PUFAs) have been known to exert anti-inflammatory effects on various disease states. However, its effect on CD8T cell-mediated immunopathology upon viral infection has not been well elucidated yet. In this study, we investigated the possible implication of-3 PUFAs in CD8T cell responses against an acute viral infection. Infection of FAT-1 transgenic mice that are capable of synthesizing-3 PUFAs from-6 PUFAs with lymphocytic choriomeningitis virus (LCMV) resulted in significant reduction of anti-viral CD8T cell responses. Interestingly, expansion of adoptively transferred wild-type (WT) LCMV-specific T cell receptor (TCR) transgenic CD8(P14) T cells into FAT-1 mice was significantly decreased. Also, activation of anti-viral CD4helper T cells was reduced in FAT-1 mice. Importantly, P14 cells carrying thegene that were adoptively transferred into WT mice exhibited a substantially decreased ability to proliferate and produce cytokines against LCMV infection. Together,-3 PUFAs attenuated anti-viral CD8T cell responses against an acute viral infection and thus could be used to alleviate immunopathology mediated by the viral infection.