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Abstract Title:

N-Acetyl cysteine effectively alleviates Coxsackievirus B-Induced myocarditis through suppressing viral replication and inflammatory response.

Abstract Source:

Antiviral Res. 2019 Dec 26:104699. Epub 2019 Dec 26. PMID: 31883926

Abstract Author(s):

Yao Wang, Shuoxuan Zhao, Yang Chen, Ying Wang, Tianying Wang, Xiaoman Wo, Yanyan Dong, Jian Zhang, Weizhen Xu, Cong Qu, Xiaofeng Feng, Xiaoyu Wu, Yan Wang, Zhaohua Zhong, Wenran Zhao

Article Affiliation:

Yao Wang

Abstract:

Viral myocarditis caused by Coxsackievirus B (CVB) infection is a severe inflammatory disease of the myocardium, which may develop to cardiomyopathy and heart failure. No effective specific treatment is available presently. Our previous study demonstrated that suppression of proinflammatory caspase-1 activation effectively inhibited CVB replication. N-acetyl cysteine (NAC) is a widely used antioxidant. In this study, we found that NAC significantly alleviated the myocardial injury caused by CVB type 3 (CVB3) under in vivo condition. Importantly, NAC treatment simultaneously suppressed viral replication and inflammatory response in both myocardium and cell culture. The antiviral and anti-inflammation mechanism of NAC, while independent of its antioxidant property, relies on its inhibition on caspase-1 activation. Moreover, NAC promotes procaspase-1 degradation via ubiquitin proteasome system, which further contributes to caspase-1 down-regulation. NAC also inhibits the activity of viral proteases. Taken together, this study shows that NAC exerts potent anti-CVB and anti-inflammation effect through targeting caspase-1. Given that NAC is a clinically approved medicine, we recommend NAC as a valuable therapeutic agent for viral myocarditis caused by CVB.

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