Effect of Nigella sativa against cisplatin induced nephrotoxicity in rats.
Ital J Food Saf. 2018 Jul 3 ;2(7):7242. Epub 2018 Jul 3. PMID: 30046560
Amnah M A Alsuhaibani
In this study, the gross composition and mineral content ofseed powder (NSP) and fatty acid composition ofoil (NSO) were investigated. The ability of NSP, extract (NSE) and NSO in reducing the effects of cisplatin-induced renal toxicity in Sprague-Dawley rats were examined. The obtained results showed that NSP contains high amounts of carbohydrates, protein, and fiber while NSO has higher amounts of linoleicacid, oleic acid, and myristic acid. Rats treated with NSP, NSO, and NSE exhibitedreducedserum levels of urea, creatinine, and potassium, and a significant increase of Na, Na/K, vitamin D, nutritional markers, and antioxidant enzymes compared to the cisplatin-induced renal toxicity group receiving noseed treatment. This study determined that all powder, oil, and extracts ofcontain potent bioactive components that may aid in treatment against cisplatininduced renal toxicity in rats.