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Abstract Title:

Nanoplastic Ingestion Enhances Toxicity of Persistent Organic Pollutants (POPs) in the Monogonont Rotifer Brachionus koreanus via Multixenobiotic Resistance (MXR) Disruption.

Abstract Source:

Environ Sci Technol. 2018 Oct 2 ;52(19):11411-11418. Epub 2018 Sep 14. PMID: 30192528

Abstract Author(s):

Chang-Bum Jeong, Hye-Min Kang, Young Hwan Lee, Min-Sub Kim, Jin-Sol Lee, Jung Soo Seo, Minghua Wang, Jae-Seong Lee

Article Affiliation:

Chang-Bum Jeong

Abstract:

Among the various materials found inside microplastic pollution, nanosized microplastics are of particular concern due to difficulties in quantification and detection; moreover, they are predicted to be abundant in aquatic environments with stronger toxicity than microsized microplastics. Here, we demonstrated a stronger accumulation of nanosized microbeads in the marine rotifer Brachionus koreanus compared to microsized ones, which was associated with oxidative stress-induced damages on lipid membranes. In addition, multixenobiotic resistance conferred by P-glycoproteins and multidrug resistance proteins, as a first line of membrane defense, was inhibited by nanoplastic pre-exposure, leading to enhanced toxicity of 2,2',4,4'-tetrabromodiphenyl ether and triclosan in B. koreanus. Our study provides a molecular mechanistic insight into the toxicity of nanosized microplastics toward aquatic invertebrates and further implies the significance of synergetic effects of microplastics with other environmental persistent organic pollutants.

Study Type : Animal Study

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