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Article Publish Status: FREE
Abstract Title:

Naringenin improves insulin sensitivity in gestational diabetes mellitus mice through AMPK.

Abstract Source:

Nutr Diabetes. 2019 Oct 7 ;9(1):28. Epub 2019 Oct 7. PMID: 31591391

Abstract Author(s):

Sen Li, Yan Zhang, Yewu Sun, Guangzhen Zhang, Jie Bai, Jianfei Guo, Xudong Su, Hongquan Du, Xi Cao, Jinkui Yang, Ting Wang

Article Affiliation:

Sen Li

Abstract:

BACKGROUND: Gestational diabetes mellitus (GDM) is a temporary form of diabetes during pregnancy, which influences the health of maternal-child in clinical practice. It is still urgent to develop new effective treatment for GDM. Naringenin is a bioactive ingredient with multiple activities including anti-diabetic. In current study, the effects of naringenin on GDM symptoms, insulin tolerance, inflammation, and productive outcomes were evaluated and the underlying mechanisms were explored.

METHODS: We administrated naringenin to GDM mice and monitored the GDM symptoms, glucose and insulin tolerance, inflammation and productive outcomes. We established tumor necrosis factor alpha (TNF-α)-induced insulin resistance skeletal muscle cell model and evaluated the effects of naringenin on reactive oxygen species (ROS) production, glucose uptake and glucose transporter type 4 (GLUT4) membrane translocation.

RESULTS: We found that naringenin ameliorated GDM symptoms, improved glucose and insulin tolerance, inhibited inflammation, and improved productive outcomes. It was further found that naringenin inhibited TNF-α-induced ROS production, enhanced GLUT4 membrane translocation, and glucose uptake, which were abolished by inhibition of AMP-activated protein kinase (AMPK).

CONCLUSION: Naringenin improves insulin sensitivity in gestational diabetes mellitus mice in an AMPK-dependent manner.

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