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Abstract Title:

Naringenin Upregulates AMPK-Mediated Autophagy to Rescue Neuronal Cells Fromβ-AmyloidEvoked Neurotoxicity.

Abstract Source:

Mol Neurobiol. 2020 Jun 16. Epub 2020 Jun 16. PMID: 32542594

Abstract Author(s):

Aitizaz Ul Ahsan, Vijay Lakshmi Sharma, Abubakar Wani, Mani Chopra

Article Affiliation:

Aitizaz Ul Ahsan

Abstract:

Deposition of an amyloid-β peptide is one of the first events in the pathophysiology of Alzheimer's disease (AD) and is clinically characterized by Aβ plaques, tau tangles, and behavioral impairments that lead to neuronal death. A substantial number of studies encourage targeting the skewness in the production and degradation of amyloid-β could be among the promising therapies in the disease. Neuronal autophagy has emerged for an essential role in the degradation of such toxic aggregate-prone proteins in various neurodegenerative diseases. We profiled a small library of common dietary compounds and identified thosethat can enhance autophagy in neuronal cells. Here we noted naringenin in silico exhibits a robust affinity with AMP-activated protein kinase (AMPK) and upregulated AMPK-mediated autophagy signaling in neurons. Naringenin can induce autophagy promoting proteins such as ULK1, Beclin1, ATG5, and ATG7in Neuro2a cells and primary mouse neurons as well. The knockdown of AMPK by siRNA-AMPK was complemented by naringenin that restored transcript levels of AMPK. Further, naringenin can reduce the levels of Aβ at a nontoxic concentration from neuronal cells. Moreover, it maintained the mitochondrialmembrane potential and resisted reactive oxygen species production, which led to the protection against Aβevoked neurotoxicity. This highlights the neuroprotective potential of naringenin that can be developed as an anti-amyloidogenic nutraceutical.

Study Type : In Vitro Study

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Sayer Ji
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