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Abstract Title:

Anti-genotoxic effect of naringin against bleomycin-induced genomic damage in human lymphocytes in vitro.

Abstract Source:

Drug Chem Toxicol. 2015 May 5:1-5. Epub 2015 May 5. PMID: 25941869

Abstract Author(s):

Dilek Yilmaz, Ozgun Teksoy, Rahmi Bilaloglu, Nilufer Çinkilic

Article Affiliation:

Dilek Yilmaz

Abstract:

Naringin is a flavonoid found in grapefruit and other citrus fruits that shows antioxidant activity. The aim of the present study was to determine the anti-genotoxic and protective effects of naringin on the chemotherapeutic/radiomimetic agent bleomycin (BLM) in human blood lymphocyte cultures in vitro using micronucleus test and chromosomal aberrations (CA) assay. We tested the three doses of naringin (1, 2, 3 µg/mL) and a single dose of BLM (20 µg/mL). BLM significantly increased the total CAs and micronucleus frequency at a concentration of 20 µg/mL. Naringin did not show any toxicity in doses of 1, 2, and 3 µg/mL. Combined treatments of BLM and naringin (2 and 3 µg/mL) significantly reduced micronucleus formation. Naringin dose-dependently decreased the total chromosome aberrations frequency induced by BLM. These results indicate that naringin could prevent BLM (20 µg/mL)-induced genotoxicity.

Study Type : In Vitro Study

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Sayer Ji
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