Naringin protects ultraviolet B-induced skin damage by regulating p38 MAPK signal pathway. - GreenMedInfo Summary
Naringin protects ultraviolet B-induced skin damage by regulating p38 MAPK signal pathway.
J Dermatol Sci. 2016 May ;82(2):106-14. Epub 2015 Dec 22. PMID: 26908354
BACKGROUND: Naringin is a bioflavonoid and has free radical scavenging and anti-inflammatory properties.
METHODS: We examined the effects of naringin on skin after ultraviolet radiation B (UVB) irradiation and the signal pathways by in vitro and in vivo assay.
RESULTS: HaCaT cells pretreated with naringin significantly inhibited UVB induced-cell apoptosis and production of intracellular reactive oxygen species (ROS). The expressions of interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8) and cyclooxygenase-2 (COX-2) in HaCaT cells pretreated with naringin were decreased compared with the only UVB group. Also, the activation of p38 induced by UVB in HaCaT cells was reversed by naringin treatments. The inhibition function of naringin on p38 activity was more obvious than JNK. In vivo, topical treatments with naringin prevented the increase of epidermal thickness, IL-6 production, cell apoptosis and the overexpression of COX-2 in BALB/c mice skin irradiated with UVB. Naringin treatment also markedly blocked the activation ofp38 in response to UVB stimulation in the mouse skin.
CONCLUSION: Naringin can effectively protect against UVB-induced keratinocyte apoptosis and skin damage by inhibiting ROS production, COX-2 overexpression and strong inflammation reactions. It seemed that naringin played its role against UVB-induced skin damage through inhibition of mitogen-activated protein kinase (MAPK)/p38 activation.