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Abstract Title:

Natural antioxidants in diabetes treatment and management: prospects of astaxanthin.

Abstract Source:

Crit Rev Food Sci Nutr. 2021 Feb 16:1-24. Epub 2021 Feb 16. PMID: 33591215

Abstract Author(s):

Osman N Kanwugu, Tatiana V Glukhareva, Irina G Danilova, Elena G Kovaleva

Article Affiliation:

Osman N Kanwugu

Abstract:

Diabetes remains a major health emergency in our entire world, affecting hundreds of millions of people worldwide. In conjunction with its much-dreaded complications (e.g., nephropathy, neuropathy, retinopathy, cardiovascular diseases, etc.) it substantially reduces the quality of life, increases mortality as well as economic burden among patients. Over the years, oxidative stress and inflammation have been highlighted as key players in the development and progression of diabetes and its associated complications. Much research has been devoted, as such, to the role of antioxidants in diabetes. Astaxanthin is a powerful antioxidant found mostly in marine organisms. Over the past years, several studies have demonstrated that astaxanthin could be useful in the treatment and management of diabetes. It has been shown to protectβ-cells, neurons as well as several organs including the eyes, kidney, liver, etc. against oxidative injuries experienced during diabetes. Furthermore, it improves glucose and lipid metabolism along with cardiovascular health. Its beneficial effects are exerted through multiple actions on cellularfunctions. Considering these and the fact that foods and natural products with biological and pharmacological activities are of much interest in the 21st-century food and drug industry, astaxanthin has a bright prospect in the management of diabetes and its complications.

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