Neem leaf extract has anticancer activity against a prostate cancer cell line. - GreenMedInfo Summary
Anticancer effects of ethanolic neem leaf extract on prostate cancer cell line (PC-3).
J Ethnopharmacol. 2006 Apr 21;105(1-2):246-50. Epub 2005 Dec 27. PMID: 16378700
Prostate cancer (PC) is the most prevalent cancer and the leading cause of male cancer death. Azadirachta indica (neem tree) has been used successfully centuries to reduce tumors by herbalists throughout Southeast Asia. Here the present study indicated that an ethanolic extract of neem has been shown to cause cell death of prostate cancer cells (PC-3) by inducing apoptosis as evidenced by a dose-dependent increase in DNA fragmentation and a decrease in cell viability. Western blot studies indicated that treatment with neem extract showed decreased level of Bcl-2, which is anti-apoptotic protein and increased the level of Bax protein. So the neem extract could be potentially effective against prostate cancer treatment.