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Article Publish Status: FREE
Abstract Title:

Neohesperidin inhibits cardiac remodeling induced by Ang II in vivo and in vitro.

Abstract Source:

Biomed Pharmacother. 2020 Jun 9 ;129:110364. Epub 2020 Jun 9. PMID: 32531678

Abstract Author(s):

Jingsi Zhang, Xiaodan Fu, Li Yang, Hongxin Wen, Lijiao Zhang, Fengyi Liu, Yu Lou, Qian Yang, Yanchun Ding

Article Affiliation:

Jingsi Zhang

Abstract:

Cardiac hypertrophy and remodeling are among the major health challenges facing countries around the world today. Neohesperidin plays an important role in influencing cell apoptosis, cell growth, tumorigenesis and tumor microenvironment, but the mechanism and role of Neohesperidin in cardiac hypertrophy and remodeling caused by Angiotensin II has not been fully elucidated. This study used Angiotensin II to induce cardiac hypertrophy and cardiac remodeling in mice. Echocardiography was used to evaluate cardiac function, H&E and Masson trichrome staining were used to detect myocardial histological changes. Cardiac cell size was determined by WGA staining. The protein content of the signaling pathway was detected by Western blot, and the mRNA expression of fibrosis and hypertrophy markers was detected by qPCR. DHE staining was used to detect oxidative stress. We also observed the effect of Neohesperidin on Ang II-induced NRCMs. The results showed that neohesperidin can significantly inhibit Ang II-induced myocardial contractile dysfunction, cardiac hypertrophy, myocardial fibrosis, myocardial oxidative stress and inflammation. These results suggest that Neohesperidin can alleviate cardiac hypertrophy and remodeling caused by Ang II, and its mechanism may be related to the inhibition of multiple signaling pathways.

Study Type : Animal Study, In Vitro Study

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