Neurobehavioral effects of bisphenol S exposure in early life stages of zebrafish larvae. - GreenMedInfo Summary
Neurobehavioral effects of bisphenol S exposure in early life stages of zebrafish larvae (Danio rerio).
Chemosphere. 2019 Feb ;217:629-635. Epub 2018 Nov 9. PMID: 30447611
As an alternate of bisphenol A (BPA), bisphenol S (BPS) is now widely used to produce our daily consumer goods. Some studies have shown that BPS has the potential to disrupt the reproduction and glucose homeostasis. However, the impact of BPS on the nervous system remains unclear. The purpose of this study is to investigate the impact of BPS on the nervous systems of zebrafish in their early growing stages. The 96 h-LCvalue of BPS to zebrafish larvae was 323 mg/L (95%CI: 308-339 mg/L). Zebrafish embryos were exposed to BPS at concentrations of 0, 0.03, 0.3 and 3.0 mg/L until 6 days postfertilization. Our results showed that 0.3 and 3.0 mg/L BPS exposure markedly decreased locomotor behavior, accompany by the increased oxidative stress, promotedapoptosis and altered retinal structure in zebrafish. In addition, the expression levels of six neurodevelopment genes (α1-tubulin, elavl3, gap43, mbp, syn2a and gfap) were downregulated after 3.0 mg/L BPS treatment. In conclusion, BPS may affect locomotor behavior and alter retinal structure inzebrafish larvae partially by increasing oxidative stress, and by suppressing the expression levels of neurodevelopment genes.