Article Publish Status: FREE
Abstract Title:

Neuroprotective and therapeutic effect ofon ischemia-induced neuronal death and cognitive impairments.

Abstract Source:

Saudi J Biol Sci. 2019 Nov ;26(7):1352-1357. Epub 2018 Aug 17. PMID: 31762595

Abstract Author(s):

Young Ock Kim, Hak Jae Kim, Gasem Mohammad Abu-Taweel, Junsang Oh, Gi-Ho Sung

Article Affiliation:

Young Ock Kim


is a type of fungus consumed by people all over the world and renowned for their nutritional benefits and herbal formulas to promote health and longevity. In the present study investigation was carried out to explore the therapeutic properties and neuroprotective effect of theon ischemic brain neuronal injury, impairment of memory and learning in experimental rats induced by a global cerebral ischemia-reperfusion injury in WISTAR rats. Vascular Dementia with transient global brain injuries induced by a four-vessel occlusion (4-VO) in WISTAR rats. Further, donepezil (5 mg/kg) andwas (100 and 300 mg/kg, p.o.) were orally administered for 7 days in 4-VO WISTAR rats.has the ability to improve memory impairments due to global cerebral ischemia and scopolamine-induced memory deterioration. Our present findings suggest thatmay be a potential candidate for the neuroprotection of hippocampus and the recovery of various vascular dementia or neuroinflammatory disorders.

Study Type : Animal Study

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