Abstract Title:

Neuroprotective effects of ethanolic extract from dryL. rhizomes.

Abstract Source:

Food Sci Biotechnol. 2021 Feb ;30(2):287-297. Epub 2021 Feb 5. PMID: 33732519

Abstract Author(s):

Kwan Joong Kim, Young Sung Jung, Dong Min You, Seung Hyun Lee, Guemsan Lee, Kang-Beom Kwon, Dae-Ok Kim

Article Affiliation:

Kwan Joong Kim


: L. rhizome has been used as a traditional medicine to treat fatigue, depression, and cognitive dysfunction. We aimed to authenticateL. rhizome using the DNA barcoding technique and to quantify its main compounds, total phenolics, total flavonoids, and antioxidant capacity, and then to investigate their neuroprotective effects. The sequences of internal transcribed spacer andofL. rhizomes showed a 99% identity with those of NCBI GenBank database according to BLAST searches. Analysis using reversed-phase HPLC revealed five main compounds inL. rhizome.L. rhizome and two bioactive compounds, salidroside and tyrosol, showed free radical scavenging activity.Lrhizome and its identified compounds protected neuronal PC-12 cells against oxidative stress and showed moderate acetylcholinesterase inhibition. Taken together, these results suggest thatLrhizomes with bioactives can be used as a functional ingredient with potential for neuroprotection.

Supplementary information: The online version of this article (doi:10.1007/s10068-020-00868-7) contains supplementary material, which is available to authorized users.

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