Article Publish Status: FREE
Abstract Title:

Neuroprotective Metabolites ofPromote Neuro-Healthy Aging.

Abstract Source:

Int J Mol Sci. 2021 Jun 15 ;22(12). Epub 2021 Jun 15. PMID: 34203691

Abstract Author(s):

Elisa Roda, Erica Cecilia Priori, Daniela Ratto, Fabrizio De Luca, Carmine Di Iorio, Paola Angelone, Carlo Alessandro Locatelli, Anthea Desiderio, Lorenzo Goppa, Elena Savino, Maria Grazia Bottone, Paola Rossi

Article Affiliation:

Elisa Roda


Frailty is a geriatric syndrome associated with both locomotor and cognitive decline, typically linked to chronic systemic inflammation, i.e.,. In the current study, we investigated the effect of a two-month oral supplementation with standardized extracts of, containing a known amount of Erinacine A, Hericenone C, Hericenone D, and L-ergothioneine, on locomotor frailty and cerebellum of aged mice. Locomotor performances were monitored comparing healthy aging and frail mice. Cerebellar volume and cytoarchitecture, together with inflammatory and oxidative stress pathways, were assessed focusing on senescent frail animals.partially recovered the aged-related decline of locomotor performances. Histopathological analyses paralleled by immunocytochemical evaluation of specific molecules strengthened the neuroprotective role ofable to ameliorate cerebellar alterations, i.e., milder volume reduction, slighter molecular layer thickness decrease and minor percentage of shrunken Purkinje neurons, also diminishing inflammation and oxidative stress in frail mice while increasing a key longevity regulator and a neuroprotective molecule. Thus, our present findings demonstrated the efficacy of a non-pharmacological approach, based on the dietary supplementation usingextract, which represent a promising adjuvant therapy to be associated with conventional geriatric treatments.

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