Abstract Title:

Neuroprotective triterpene saponins from the leaves of.

Abstract Source:

Nat Prod Res. 2019 Oct 22:1-7. Epub 2019 Oct 22. PMID: 31638430

Abstract Author(s):

Ji-Wu Huang, Yi-Qian Du, Chuang-Jun Li, Jing-Zhi Yang, Jie Ma, Ying-Da Zang, Nai-Hong Chen, Dong-Ming Zhang

Article Affiliation:

Ji-Wu Huang


Two new triterpene saponins, namely notoginsenoside Ng5 () and notoginsenoside Ng6 () were isolated from the leaves of, along with five known ones. Their structures were determined by chemical methods, NMR and X-ray experiments. The absolute configuration of compoundwith four sugar units was confirmed by single crystal X-ray analysis. Compoundsandinhibited PC12 cell damage induced by serum deprivation, and increased cell viability from 58.7 ± 6.7% to 66.7 ± 4.5%, 76.1 ± 6.1%, 64.7 ± 5.2% and 67.2 ± 5.0% at 10 μM, respectively.

Study Type : In Vitro Study
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