Neuroprotective triterpene saponins from the leaves of Panax notoginseng. - GreenMedInfo Summary
Neuroprotective triterpene saponins from the leaves of.
Nat Prod Res. 2019 Oct 22:1-7. Epub 2019 Oct 22. PMID: 31638430
Two new triterpene saponins, namely notoginsenoside Ng5 () and notoginsenoside Ng6 () were isolated from the leaves of, along with five known ones. Their structures were determined by chemical methods, NMR and X-ray experiments. The absolute configuration of compoundwith four sugar units was confirmed by single crystal X-ray analysis. Compoundsandinhibited PC12 cell damage induced by serum deprivation, and increased cell viability from 58.7 ± 6.7% to 66.7 ± 4.5%, 76.1 ± 6.1%, 64.7 ± 5.2% and 67.2 ± 5.0% at 10 μM, respectively.