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Abstract Title:

A new antitumor arabinopyranoside from Laurencia majuscula induces G2/M cell cycle arrest.

Abstract Source:

Phytother Res. 2010 Oct ;24(10):1447-50. PMID: 20878692

Abstract Author(s):

Bin Du, Xueyun Zhong, Xiaojian Liao, Wenjie Xu, Xulong Zhou, Shihai Xu

Article Affiliation:

Bin Du

Abstract:

A new arabinopyranoside was isolated from the alga Laurencia majuscula (Harvey) Lucas, collected from the Xisha Islands in the South China Sea. Its structure was elucidated as hexadecyl-1-O-α-L-arabinopyranoside by spectroscopic analysis. It was found that arabinopyranoside had significant antitumor activity in LOVO and Bel-7402 cell lines. Flow cytometric analysis showed that arabinopyranoside arrested the cell cycle in the G2/M phase. Western blotting demonstrated that the protein expression of CDK1 and cyclin A related to the G2/M phase decreased markedly with arabinopyranoside treatment, with slight changes in cyclin B1 expression. Taken together, the findings identify a potential new antitumor therapeutic arabinopyranoside isolated from red alga Laurencia majuscula.

Study Type : In Vitro Study

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