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Abstract Title:

New bis-thioglycosyl-1,1'-disulfides from Nasturtium officinale R. Br. and their anti-neuroinflammatory effect.

Abstract Source:

Bioorg Chem. 2019 Jan 31 ;86:501-506. Epub 2019 Jan 31. PMID: 30776680

Abstract Author(s):

Tae Hyun Lee, Zahra Khan, Lalita Subedi, Sun Yeou Kim, Kang Ro Lee

Article Affiliation:

Tae Hyun Lee

Abstract:

As a part of our continuing search for bioactive constituents from Brassicaceae family, three new bis-thioglycosides (1-3) were isolated from the 80% MeOH extract of Nasturtium officinale, together with 13 known compounds (4-16). The chemical structures of three new bis-thioglycosides (1-3) were elucidated using NMR techniques (H andC NMR,H-H COSY, HSQC, and HMBC), HRESIMS, and a chemical method. All the compounds were evaluated for their inhibitory effects on nitric oxide (NO) levels in lipopolysaccharide (LPS)-stimulated murine microglia BV-2 cells. Among the isolates, compound 5 exhibited a strong inhibitory effect on NO production, and compounds 4 and 15 showed moderate inhibitory activities, suggesting the neuroprotective and anti-neuroinflammatory effects of bis-thioglycosides from N. officinale.

Study Type : In Vitro Study

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