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Article Publish Status: FREE
Abstract Title:

New Iridoid Derivatives from the Fruits ofand Their Neuroprotective Activities.

Abstract Source:

Molecules. 2019 Feb 11 ;24(3). Epub 2019 Feb 11. PMID: 30754635

Abstract Author(s):

Lin-Lin Ji, Xin Wang, Jin-Jie Li, Xiang-Jian Zhong, Bo Zhang, Jing Juan, Xiao-Ya Shang

Article Affiliation:

Lin-Lin Ji

Abstract:

Three previously undescribed iridoids, cornusfurals A⁻C, were isolated from the ethanolic extracts of fruits of. Their structures were elucidated by spectroscopic methods, including one-dimensional and two-dimensional nuclear magnetic resonance, ultraviolet spectroscopy, infrared spectroscopy, and mass spectrometry. The neuroprotective activity was evaluated by measuring corticosterone-induced damage in PC12 cells. The results showed that cornusfural B decreased corticosterone-induced PC12 cell damage compared with that in model cells.

Study Type : In Vitro Study

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Sayer Ji
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