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Abstract Title:

New tirucallane-type triterpenoids from the resin of Boswellia carteriiand their NO inhibitory activities.

Abstract Source:

Chin J Nat Med. 2021 Sep ;19(9):686-692. PMID: 34561080

Abstract Author(s):

Fang-Shen Liu, Ting-Ting Zhang, Jun Xu, Qin-Xue Jing, Chi Gong, Bang-Jian Dong, Da-Hong Li, Xiao-Qiu Liu, Zhan-Lin Li, Zhong Yuan, Hui-Ming Hua

Article Affiliation:

Fang-Shen Liu

Abstract:

Six new tirucallane-type triterpenoids (1-6), along with ten known triterpenoids, were isolated from methylene chloride extract of the resin of Boswellia carterii Birdw. By the application of the comprehensive spectroscopic data, the structures of the compounds were clarified. The experimental electronic circular dichroism spectra were compared with those calculated, which allowed to assign the absolute configurations. Compounds 5 and 6 possesed a 2, 3-seco tirucallane-type triterpenoid skeleton, which were first reported. Their inhibitory activity against NO formation in LPS-activated BV-2 cells were evaluated. Compound 9 showed appreciable inhibitory effect, with an ICvalue of 7.58± 0.87 μmol·L.

Study Type : In Vitro Study

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