Abstract Title:

A new LED device used for photodynamic therapy in treatment of moderate to severe Acne vulgaris.

Abstract Source:

Photodiagnosis Photodyn Ther. 2015 Jun 23. Epub 2015 Jun 23. PMID: 26116283

Abstract Author(s):

Yiyun Dong, Guoyu Zhou, Jinan Chen, Lingyue Shen, Zhao Jianxin, Qing Xu, Yulan Zhu

Article Affiliation:

Yiyun Dong

Abstract:

OBJECTIVE: This study investigated the efficacy and safety of a newly designed LED device used in photodiagnosis and photodynamic therapy of moderate to severe acne vulgaris in Chinese patients.

METHODS: Forty-six patients with moderate to severe facial acne showing high degrees of fluorescence by ultraviolet light examination were illuminated during ALA-PDT with two wavelengths of light (543-548nm, and 630± 6nm, respectively) after 2h of incubation with ALA. Each patient received treatment once every 30 days for two or three sessions. Two independent investigators assigned an acne severity score at baseline, one week after each treatment, as well as 4, 8, and 12 weeks after the completion of treatment. Adverse effects were recorded during and after each treatment. All patients rated their satisfaction with the results of treatment at a 12-week follow up visit.

RESULTS: The ALA-PDL treatment regimen showed an overall effectiveness rate of 89.13% (41/46 patients). Some degree of clinical efficacy was seen in 71.42%, 86.67%, and 95.83% of patients with grades IV, V, and VI acne, respectively, and the rate of clinical effectiveness increased with increasing acne severity. When compared with baseline scores, significant reductions in acne scores were obtained at 8, and 12 weeks after completion of treatment. Maximum efficacy was shown at the 12 week follow up. No severe adverse events were observed.

CONCLUSION: ALA-PDT administered with the newly designed LED device was an effective treatment for moderate to severe acne vulgaris, and side effects were mild and reversible.

Study Type : Human Study

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Sayer Ji
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