Nicolau syndrome induced by intramuscular vitamin K in a premature newborn.
Eur J Pediatr. 2009 Dec;168(12):1541-2. Epub 2009 Mar 11. PMID: 19277707
Division of Neonatology, Department of Pediatrics, Gulhane Military Medical Academy, Ankara, Turkey. email@example.com
INTRODUCTION: Nicolau syndrome (NS), also known as livedo-like dermatitis or embolia cutis medicamentosa, is a very rare complication of intramuscular and intraarticular injection of various drugs. CASE REPORT: We herein report a case of NS developing approximately 2 h after the intramuscular administration of vitamin K1 in an extremely low birth weight premature newborn. To our knowledge, this patient is the youngest case suffering from such a livedoid skin necrosis and the first case of neonatal NS developing due to intramuscular administration of vitamin K1.