n/a
Article Publish Status: FREE
Abstract Title:

Melanoma and non-melanoma skin cancer chemoprevention: a role for nicotinamide?

Abstract Source:

Photodermatol Photoimmunol Photomed. 2017 Jul 5. Epub 2017 Jul 5. PMID: 28681504

Abstract Author(s):

Rashi Minocha, Diona L Damian, Gary M Halliday

Article Affiliation:

Rashi Minocha

Abstract:

Ultraviolet radiation (UVR) causes DNA damage in melanocytes by producing photolesions such as cyclobutane pyrimidine dimers and 8-oxo-7-hydrodeoxyguanosine. The production of reactive oxygen species by UVR also induces inflammatory cytokines that, together with the inherent immunosuppressive properties of UVR, propagate carcinogenesis. Nicotinamide (Vitamin B3 ) enhances DNA repair, modulates the inflammatory environment produced by UVR and reduces UV-induced immunosuppression. As nicotinamide reduces the incidence of actinic keratoses and non-melanoma skin cancers in high-risk individuals, and enhances repair of DNA damage in melanocytes, it is a promising agent for the chemoprevention of melanoma in high-risk populations. This article is protected by copyright. All rights reserved.

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.