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Abstract Title:

Histological Effects of Nigella Sativa on Aspirin-Induced Nephrotoxicity in Albino Rats.

Abstract Source:

J Coll Physicians Surg Pak. 2018 Oct ;28(10):735-738. PMID: 30266114

Abstract Author(s):

Sania Asif, Sitwat Mudassir, Rabia Sajjad Toor

Article Affiliation:

Sania Asif

Abstract:

OBJECTIVE: To determine the histological effects of Nigella sativa on kidneys against aspirin-induced nephrotoxicity in albino rats.

STUDY DESIGN: An experimental study.

PLACE AND DURATION OF STUDY: Anatomy Department, University of Health Sciences, Lahore, from January 2014 to December 2015.

METHODOLOGY: Thirty-two rats were equally divided into four groups A, B, C and D of eight animals each. Group A (control) was provided with single oral dose of 10 mg/100 gm body weight of 1% methyl cellulose. Group B (experimental group) and C (self recovery group) were provided with single oral dose of 1000 mg/kg aspirin. Group D was provided with 250 mg/kg ethanolic extract of Nigella sativa followed by 1000 mg/kg aspirin by oral gavage, after that only extract of Nigella sativa was given for seven days. Animals of groups A, C and D were sacrificed on the 8th day of experiment and that of group B on the second day of experiment. Kidneys were excised and fixed in 10% formalin solution. Hematoxylin, eosin and periodic acid Schiff's reagents were used to stain the kidney tissues. Histological slides were prepared to study proximal convoluted tubules.

RESULTS: Histological parameters were normal in control group A. Significant impairment was present in group B. There was no self-recovery in group C. Significant improvement was present in all the parameters of group D.

CONCLUSION: Nigella sativa has protective effect on aspirin-induced nephrotoxicity in rats.

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