Article Publish Status: FREE
Abstract Title:


Abstract Source:

Acta Endocrinol (Buchar). 2019 Jul-Sep;15(3):289-294. PMID: 32010345

Abstract Author(s):

E Altun, E Avci, T Yildirim, S Yildirim

Article Affiliation:

E Altun


Background: To evaluate the protective effect ofoil (NSO) on the myocardium in streptozotocin-induced diabetic rats.

Materials and methods: Thirty-two 7-8-week-old female Wistar albino rats (300-350 g) were equally divided into 4 groups: nondiabetic untreated animals (control), diabetes mellitus (DM), NSO, and DM+NSO groups. For the induction of diabetes, 45 mg/kg streptozotocin was applied to the rats in the DM and DM+NSO groups as a single intraperitoneal dose. NSO (400 mg/kg) was orally administered through an intragastric catheter once a day over 21 days. Formalin-fixed, paraffin-embedded tissue sections of the myocardium were evaluated histopathologically and immunohistochemically.

Results: Compared to the control, NSO, and DM+NSO groups, the myocardial tissue samples from the rats in the DM group had significantly higher myositis, hyaline degeneration, and Zenker's necrosis. Moreover, the Bcl-2 expressions were significantly higher in the control, NSO, and DM+NSO groups than in the DM group.

Conclusion: NSO has a protective effect on the myocardium of streptozotocin-induced diabetic rats, most likely via suppressing apoptosis.

Study Type : Animal Study

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Sayer Ji
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