PROTECTIVE EFFECT OFOIL ON MYOCARDIUM IN STREPTOZOTOCIN-INDUCED DIABETIC RATS.
Acta Endocrinol (Buchar). 2019 Jul-Sep;15(3):289-294. PMID: 32010345
Background: To evaluate the protective effect ofoil (NSO) on the myocardium in streptozotocin-induced diabetic rats.
Materials and methods: Thirty-two 7-8-week-old female Wistar albino rats (300-350 g) were equally divided into 4 groups: nondiabetic untreated animals (control), diabetes mellitus (DM), NSO, and DM+NSO groups. For the induction of diabetes, 45 mg/kg streptozotocin was applied to the rats in the DM and DM+NSO groups as a single intraperitoneal dose. NSO (400 mg/kg) was orally administered through an intragastric catheter once a day over 21 days. Formalin-fixed, paraffin-embedded tissue sections of the myocardium were evaluated histopathologically and immunohistochemically.
Results: Compared to the control, NSO, and DM+NSO groups, the myocardial tissue samples from the rats in the DM group had significantly higher myositis, hyaline degeneration, and Zenker's necrosis. Moreover, the Bcl-2 expressions were significantly higher in the control, NSO, and DM+NSO groups than in the DM group.
Conclusion: NSO has a protective effect on the myocardium of streptozotocin-induced diabetic rats, most likely via suppressing apoptosis.