Anti-Inflammatory, Anti-Arthritic and Anti-Nociceptive Activities ofOil in a Rat Model of Arthritis.
Antioxidants (Basel). 2019 Aug 25 ;8(9). Epub 2019 Aug 25. PMID: 31450670
This study investigated the preventive efficacy of the crude oil extracted fromseeds in a rat model of arthritis induced by using complete Freund's adjuvant (CFA).oil at 1.82 mL/kg or 0.91 mL/kg (corresponding to 1596 and 798 mg/kg, respectively) was orally administered for 25 days from the day of immunization. One immunized group was treated orally with indomethacin (3 mg/kg) as a reference drug. Body weight growth rate, paw swelling, arthritis score, mechanical allodynia, locomotor activity and anxiety-like behavior were observed, and the levels of Interleukin 6 (IL-6), C-reactive protein, albumin and total cholesterol in plasma were measured on days 15 and 25.oil showed anti-inflammatory, anti-arthritic and anti-nociceptive activities that were significant as compared to untreated arthritic rats but less than indomethacin. These results indicated thatoil significantly attenuated adjuvant-arthritis in rats and the higher dose (1.82 mL/kg) prevented the development of arthritis with an inhibition of 56%.