Nigerian propolis: chemical composition, antioxidant activity andα-amylase and α-glucosidase inhibition.
Nat Prod Res. 2019 Nov 8:1-5. Epub 2019 Nov 8. PMID: 31698954
Chinwendum Stephenie Alaribe
Propolis is an attractive natural ingredient to design health products due to its pharmacological effects. Our chemical investigation of a polar extract of Nigerian propolis (NP) led the isolation and identification of five isoflavonoids (,), one diarylpropane () and one prenylated flavanone () by the combination of chromatographic and spectroscopic techniques. Compounds,andwere found to be the main markers in NP (8.0, 5.0 and 4.0 mg/g of dry extract, respectively). Moreover, NP and its phenolic constituents exhibitedfree radical scavenging activity together with a promising antidiabetic effect againstα-amylase and α-glucosidase enzymes. Finally, NP showed also a moderate inhibition ofgrowth. These results suggested that NP could be a good candidate in nutraceuticals and food products.