Antidiabetic Effect of Fresh Nopal () in Low-Dose Streptozotocin-Induced Diabetic Rats Fed a High-Fat Diet.
Evid Based Complement Alternat Med. 2017 ;2017:4380721. Epub 2017 Feb 20. PMID: 28303158
Seung Hwan Hwang
The objective of the present study was to evaluate-glucosidase inhibitory and antidiabetic effects of Nopal water extract (NPWE) and Nopal dry power (NADP) in low-dose streptozotocin- (STZ-) induced diabetic rats fed a high-fat diet (HFD). The type 2 diabetic rat model was induced by HFD and low-dose STZ. The rats were divided into four groups as follows: (1) nondiabetic rats fed a regular diet (RD-Control); (2) low-dose STZ-induced diabetic rats fed HFD (HF-STZ-Control); (3) low-dose STZ-induced diabetic rats fed HFD and supplemented with NPWE (100 mg/kg body weight, HF-STZ-NPWE); and (4) low-dose STZ-induced diabetic rats fed HFD and supplemented with comparison medication (rosiglitazone, 10 mg/kg, body weight, HF-STZ-Rosiglitazone). In results, NPWE and NADP had ICvalues of 67.33 and 86.68 g/mL, both of which exhibit inhibitory activities but lower than that of acarbose (38.05 g/mL) while NPWE group significantly decreased blood glucose levels compared to control and NPDP group on glucose tolerance in the high-fat diet fed rats model (<0.05). Also, the blood glucose levels of HR-STZ-NPWE group were significantly lower (<0.05) than HR-STZ-Control group on low-dose STZ-induced diabetic rats fed HFD. Based on these findings, we suggested that NPWE could be considered for the prevention and/or treatment of blood glucose and a potential use as a dietary supplement.