Notoginsenoside R7 suppresses cervical cancer. - GreenMedInfo Summary
Notoginsenoside R7 suppresses cervical cancer via PI3K/PTEN/Akt/mTOR signaling.
Oncotarget. 2017 Dec 12 ;8(65):109487-109496. Epub 2017 Nov 27. PMID: 29312623
Notoginsenoside R7 was isolated from, a plant used commonly in traditional Chinese medicine. We investigated the anti-cancer effects of R7 in HeLa cellsand, and explored the underlying mechanisms of action. R7 dose-dependently inhibited HeLa cell proliferation and induced apoptosis,docking-based screening assays showed that R7 can directly bind Akt. Pretreatment with the Akt inhibitor LY294002 synergistically enhanced the R7 anti-proliferation and anti-apoptosis effects in HeLa cells, confirming that R7 acts through the PI3K/Akt pathway. Consistent with thefindings, R7 exerted anti-tumor effects in a mouse xenograft model by targeting PI3K (PTEN) and Akt, activating the pro-apoptotic Bcl-2 family and, subsequently, caspase family members. R7 treatment activated PTEN and downregulated mTOR phosphorylation without affecting mTOR expression, though regulatory-associated protein of mTOR (raptor) expression declined. Our study suggests that R7 is a promising chemotherapeutic agent for the treatment of cervical cancer and other PI3K/PTEN/Akt/mTOR signaling-associated tumors.