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Article Publish Status: FREE
Abstract Title:

A Novel Herbal Hydrogel Formulation offor Wound Healing.

Abstract Source:

Plants (Basel). 2020 Dec 24 ;10(1). Epub 2020 Dec 24. PMID: 33374419

Abstract Author(s):

Aaliya Ali, Prakrati Garg, Rohit Goyal, Gurjot Kaur, Xiangkai Li, Poonam Negi, Martin Valis, Kamil Kuca, Saurabh Kulshrestha

Article Affiliation:

Aaliya Ali

Abstract:

Treatment of wounds is essential as the wound can also be lethal at some point in time if not healed properly. Ethnomedicinal plants can treat wounds as they have no side effects, whereas, in the case of chemical drugs, the side effects are on the rise. In this study, seeds ofwhich is the essential ethnomedicinal plant, were studied for wound healing efficacy. The study was planned for the assessment of in vitro (antioxidant and antimicrobial activities) and in vivo (excision and incision wound healing models) wound healing efficacy of n-hexane extract and hydrogels ofseeds. The antioxidant and antimicrobial activities were assessed by DPPH free radical scavenging assay and Agar well diffusion method, respectively. In excision and incision wound models, Swiss albino mice were used for wound healing efficacy of hydrogels, i.e., 5% and 10% hexane extracts ofseeds. The n-hexane extract showed antioxidant as well as antibacterial activities. Moreover, the hydrogels formulated using n-hexane extract ofseeds showed significant wound healing activity compared to both control and standard until the end of the protocol in both the models. Furthermore, the histopathological investigation confirmed the findings of accelerated regeneration of tissue accompanied by a decrease in inflammatory cells and increased vascularity of the immediate skin. The results (both in vitro and in vivo) claimed conclusively that our n-hexane hydrogel formulation ofseeds might serve as an alternative therapy in skin restoration during wound healing.

Study Type : In Vitro Study

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