n/a
Abstract Title:

A novel Hericium erinaceus polysaccharide: Structural characterization and prevention of HO-induced oxidative damage in GES-1 cells.

Abstract Source:

Int J Biol Macromol. 2019 Nov 20. Epub 2019 Nov 20. PMID: 31759012

Abstract Author(s):

Bingwu Liao, Chunhui Zhou, Tingting Liu, Yangyan Dai, Huihua Huang

Article Affiliation:

Bingwu Liao

Abstract:

In this paper, the structural characteristics and bioactivity of a novel polysaccharide from H. erinaceus (HEP) were investigated, wherein, physico-chemical characterization demonstrated that HEPwith an average molecular weight of 12.713 kDa was composed of mannose (5.13%), glucose (43.02%), and galactose (51.85%). The models in vitro for preventing oxidative damage of human gastric epithelium (GES-1) cells were established and used to investigate the preventive effects of HEPfrom oxidative damage. It was found that HEPcould significantly prevent GES-1 cells against HO-induced oxidative damage by promoting cell proliferation, inhibiting cell necrosis, reducing ROS levels, regulating mitochondrial membrane potential and maintaining mitochondrial membrane permeability. These results indicated HEPcan effectively prevent gastric cell damage in vitro and suggested the potential application of HEPas bioactive ingredient for healthy foods.

Print Options


Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.