Abstract Title:

Nut consumption and the risk of oesophageal squamous cell carcinoma in the Golestan Cohort Study.

Abstract Source:

Br J Cancer. 2018 Jun 28. Epub 2018 Jun 28. PMID: 29950612

Abstract Author(s):

Maryam Hashemian, Gwen Murphy, Arash Etemadi, Hossein Poustchi, Maryam Sharafkhah, Farin Kamangar, Akram Pourshams, Akbar Fazeltabar Malekshah, Masoud Khoshnia, Abdolsamad Gharavi, Azita Hekmatdoost, Paul J Brennan, Paolo Boffetta, Sanford M Dawsey, Christian C Abnet, Reza Malekzadeh

Article Affiliation:

Maryam Hashemian


BACKGROUND: Nut consumption has been inversely associated with gastric cancer incidence in US-based studies, but not with oesophageal cancer. However, there is aetiologic heterogeneity, among oesophageal squamous cell carcinoma (ESCC) cases in low-risk vs. high-risk populations. The objective of this study was to evaluate the association between nut consumption and risk of ESCC in a high-risk population.

METHODS: The Golestan Cohort Study enroled 50,045 participants in Northeastern Iran, between 2004 and 2008. Intake of peanuts, walnuts and mixed nuts (including seeds) were assessed using a validated food frequency questionnaire at baseline. Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals for subsequent ESCC adjusted for potential confounders. Non-consumers of nuts were used as the reference category and the consumers were categorised into tertiles.

RESULTS: We accrued 280 incident ESCC cases during 337,983 person-years of follow up. Individuals in the highest tertiles of total nut consumption, and mixed nut consumption were significantly associated with lower risk of developing ESCC compared to non-consumers (HR = 0.60, 95% CI = 0.39-0.93, p-trend = 0.02, and HR = 0.52, 95% CI = 0.32-0.84, p trend = 0.002, respectively).

CONCLUSIONS: We found a statistically significant inverse association between total nut consumption and the risk of ESCC in this high-risk population.

Study Type : In Vitro Study

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