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Article Publish Status: FREE
Abstract Title:

Inhibitory Effect ofFruit Water Extract on Solar Ultraviolet-Induced MMP-1 Expression.

Abstract Source:

Int J Mol Sci. 2018 Aug 24 ;19(9). Epub 2018 Aug 24. PMID: 30149526

Abstract Author(s):

Ah-Ram Han, Tae-Gyu Lim, Young-Ran Song, Mi Jang, Young Kyoung Rhee, Hee-Do Hong, Mi-Hyun Kim, Hyun-Jin Kim, Chang-Won Cho

Article Affiliation:

Ah-Ram Han

Abstract:

is a type of cactus whose fruits have been used in folk medicine for the treatment of several diseases. In the present study, we aimed to determine whetherfruit water extract (OHE) has inhibitory effects against solar ultraviolet (sUV)-induced matrix metalloproteinase-1 (MMP-1) expression. In ex vivo human skin, we found that OHE suppressed sUV radiation-induced MMP-1 expression. The inhibitory effect of OHE was confirmed in human dermal fibroblasts. OHE treatment reduced sUV-induced MMP-1 expression by suppressing reactive oxygen species (ROS) generation and phosphorylation of c-Jun, a component of transcription factor activator protein 1 (AP-1). On the other hand, OHE recovered the tissue inhibitor of matrix metalloproteinase 1 (TIMP-1) and type 1 collagen production attenuated by sUV. As upstream signaling pathways for AP-1, MKK4-JNK, MEK-ERK, and MKK3/6-p38 phosphorylation were downregulated by OHE treatment. In addition, OHE exhibited DPPH radical scavenging activity. These findings demonstrate that OHE has a preventive effect against sUV-induced skin damage via suppression of pathways triggered by ROS.

Study Type : In Vitro Study

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