Protective and anti-inflammatory effects of hydroalcoholic leaf extract of Origanum vulgare on oxidative stress, TNF-α gene expression and liver histological changes in paraquat-induced hepatotoxicity in rats.
Arch Physiol Biochem. 2018 Feb 9:1-8. Epub 2018 Feb 9. PMID: 29425067
CONTEXT: Toxicity with paraquat can lead to serious damages to the liver.
OBJECTIVE: The study investigates the protective effects of Origanum vulgare leaf extract against paraquat liver damage.
MATERIAL AND METHODS: Rats were divided into six groups. Group 1, the control group; group 2, rats that received paraquat only; group 3, rats that received paraquat plus silymarin; and groups 4, 5, and 6 were treated with paraquat and O. vulgare leaf extract. Then, the serum and tissue parameters of the oxidative stress were examined.
RESULTS: In group 2, paraquat caused a remarkable increase in the level of serum ALT, AST, ALP, lipid profiles, and liver TNF-α gene expression compared to group 1. The groups which received O. vulgare leaf extract exhibited significant ameliorations in abnormalities of paraquat-induced liver damage and serum biochemical parameters.
CONCLUSION: O. vulgare leaf extract has inhibitory effects on paraquat-induced liver damage due to its antioxidant properties.