Oat proteins and beta-glucan have a synergistic anticholesterolemic effect. - GreenMedInfo Summary
Effects of dietary oat proteins on cholesterol metabolism of hypercholesterolaemic hamsters.
J Sci Food Agric. 2016 Mar 15 ;96(4):1396-401. Epub 2015 May 21. PMID: 25913820
BACKGROUND: The aim of present study was to investigate the hypocholesterolaemic effects of oat proteins (OP) in hamsters fed with a hypercholesterolaemic diet. The hamsters were divided into five groups and fed with the experimental diets containing oat, OP, oatβ-glucan (OG), or OP+OG for 30 days.
RESULTS: OP and the OG significantly lowered the concentrations of plasma low-density lipoprotein-cholesterol and liver total cholesterol (TC), and increased the excretion of faecal bile acid and TC. Plasma and liver TC in the OP+OG group were significantly lower than those in the OP or OG groups. Both OP and OG increased the activity of liver cholesterol 7α-hydroxylase (CYP7A1), while its activity in the OP+OG group was strongly increased compared with the OP or OG groups.
CONCLUSION: These results indicated that dietary OP could improve hypercholesterolaemia, while dietary OP and OG together would have better hypocholesterolaemic effects.